Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.
From inside the subanalyses, victims whose lovers used condoms completely of the time have been put into a few groups based on the responses to help you practical question “Performed their lover’s manhood actually touch the hole of the genitals instead of a great condom?” If subjects constantly responded “no” for each operate out of vaginal sex from inside the 7-times several months, these were coded because that have got “zero genital get in touch with without an effective condom.” Analyses have been did due to the fact revealed more than, having four kinds of the frequency out of condom explore (completely without the genital get in touch with instead of an excellent condom, completely with some or an unidentified regularity out of vaginal contact rather than a good condom, and you may three teams less than 100 %, once the discussed above).
Furthermore, Cox proportional-hazards activities were used to choose chance activities on the detection regarding event cervical squamous intraepithelial lesions for the eight months just before certain Pap shot (based on an earlier observance that almost all sores exists soon after experience infection 23 ). A great 51-go out lag before each head to is integrated as the 51 days try the fresh new quickest observed period between your date a female basic had gender in addition to date from recognition off an instance lesion in this study. Investigation to have such as sufferers had been censored after the basic detection away from an instance lesion.
Overall performance
New imply (±SD) age this new 82 subjects during the enrollment are 19.3±0.seven decades. The fresh new subjects complete 709 check outs. The brand new mean pursue-upwards big date are 33.9±11.8 months, the indicate quantity of check outs for every single woman try 8.6±2.nine, in addition to median time taken between visits was cuatro.step one months. Journal investigation was Single Parent dating app in fact ninety.7 per cent complete, and you can condom research was indeed filed toward 99.step three % off days you to definitely intercourse was reported.
Table 2
The new a dozen-few days collective chance of an initial HPV infection immediately after first gender is 37.2 percent (95 per cent count on interval, twenty-seven.2 to help you 44.cuatro percent). A total of 126 incident style of-particular attacks were known within the forty women once they first got sex ( Desk dos ). Experience infection had been identified in the about three females before it claimed which have gender for the first time, along with that self-confident having HPV particular 51, you to getting HPV kind of six, plus one getting HPV types forty, 61, and you can 66. Brand new 24-few days cumulative chance regarding cervical squamous intraepithelial lesions are fifteen.0 per cent (95 per cent believe period, 8.3 so you can 26.dos per cent).
